San Francisco and New York are notorious for their high cost of living. While the startup scene on those two cities is great, the downside is even a $100K+ salary means a mediocre living standards.
What are some other cities here in the US where there is a decent startup scene and cost effective to live in.
In the suburbs one can live far better on a $50K salary but then it's hard to find talent, or convince talented people to move there to work with you on your startup.
Provo, Utah, or anywhere in Utah. Provo (or it's northern surrounding metro) is more of the "startup/tech" scene, though.
Maybe look at some of the hipster havens like Portland, Oregon. These kind of places normally have more entrepeneurs per capita, and also is easier to recruit to than Nowhere, Alaska. And even though prices are rising, it's no where near NYC etc.
Disclaimer: I'm not from the US myself.